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[碳环化合物抗病毒作用的特征取决于其浓度]

[Features of the antiviral effect of carbocyclic compounds depending on their concentration].

作者信息

Boreko E I, Pavlova N I, Votiakov V I

出版信息

Vopr Virusol. 1996 May-Jun;41(3):129-33.

PMID:8928507
Abstract

Antiviral agents and new agents possessing antiviral properties and characterized by a carbocyclic (carcass) structure were shown to differ from other, specifically, heterocyclic compounds, by the presence of a range from the maximally effective to maximally tolerable concentrations, the antiviral effect decreasing in this range of concentrations. This feature was observed in cell cultures, chick embryos, and laboratory animals in experiments with different influenza viruses and RS virus.

摘要

具有抗病毒特性且以碳环(骨架)结构为特征的抗病毒药物和新型药物,已显示出与其他特别是杂环化合物不同,它们存在一个从最大有效浓度到最大耐受浓度的范围,在此浓度范围内抗病毒效果会降低。在针对不同流感病毒和呼吸道合胞病毒的实验中,在细胞培养物、鸡胚和实验动物中都观察到了这一特征。

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