血管性痴呆和阿尔茨海默病型痴呆的质子磁共振波谱分析
Proton magnetic resonance spectroscopy of vascular- and Alzheimer-type dementia.
作者信息
Kattapong V J, Brooks W M, Wesley M H, Kodituwakku P W, Rosenberg G A
机构信息
Department of Neurology, University of New Mexico School of Medicine, Albuquerque, USA.
出版信息
Arch Neurol. 1996 Jul;53(7):678-80. doi: 10.1001/archneur.1996.00550070116019.
OBJECTIVE
To identify biochemical differences in brain tissue between patients with dementia of the Alzheimer type and vascular dementia.
DESIGN AND SUBJECTS
Proton magnetic resonance spectroscopy was used to compare 10 patients with dementia of the Alzheimer type and 8 age-matched patients with vascular dementia.
RESULTS
The ratios of N-acetyl groups to creatine and N-acetyl groups to choline were lower in regions of subcortical white matter in patients with vascular dementia than in patients with dementia of the Alzheimer type (P < .02).
CONCLUSION
Proton magnetic resonance spectroscopy may be useful in distinguishing between dementia of the Alzheimer type and vascular dementia.
目的
确定阿尔茨海默型痴呆患者与血管性痴呆患者脑组织中的生化差异。
设计与研究对象
采用质子磁共振波谱法对10例阿尔茨海默型痴呆患者和8例年龄匹配的血管性痴呆患者进行比较。
结果
血管性痴呆患者皮质下白质区域中N - 乙酰基与肌酸的比率以及N - 乙酰基与胆碱的比率低于阿尔茨海默型痴呆患者（P < .02）。
结论
质子磁共振波谱法可能有助于区分阿尔茨海默型痴呆和血管性痴呆。
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