Biver F, Lotstra F, Monclus M, Wikler D, Damhaut P, Mendlewicz J, Goldman S
PET-Biomedical Cyclotron Unit, Erasme Hospital, Free University of Brussels, Belgium.
Neurosci Lett. 1996 Feb 2;204(1-2):25-8. doi: 10.1016/0304-3940(96)12307-7.
Serotonergic mechanisms are involved in gender-related behaviors and psychiatric conditions like aggression, eating disorders, depression, impulsivity or suicide. We studied gender differences in the living human brain type-2 serotonin receptor (5HT2r). Twenty-two healthy age-matched men and women were investigated using positron emission tomography and the selective radiotracer, 18F-labeled altanserin. Binding was quantified using a non-linear least-squares minimization procedure. We found significantly higher 5HT2r binding capacity in men than in women, especially in the frontal and cingulate cortices. Distinct liability for men and women to suffer from some psychiatric disorders responding to serotonergic agents may be related to differences in brain serotonin receptors.
血清素能机制参与了与性别相关的行为以及诸如攻击性、饮食失调、抑郁症、冲动或自杀等精神疾病。我们研究了活体人类大脑中2型血清素受体（5HT2r）的性别差异。使用正电子发射断层扫描和选择性放射性示踪剂18F标记的阿坦色林对22名年龄匹配的健康男性和女性进行了研究。使用非线性最小二乘法最小化程序对结合进行定量。我们发现男性的5HT2r结合能力显著高于女性，尤其是在额叶和扣带回皮质。男性和女性患某些对血清素能药物有反应的精神疾病的不同易感性可能与大脑血清素受体的差异有关。
