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使用DEREK系统对美国国家毒理学计划目前正在测试的30种化学物质进行啮齿动物致癌性预测。DEREK协作组。

Prediction of rodent carcinogenicity using the DEREK system for 30 chemicals currently being tested by the National Toxicology Program. The DEREK Collaborative Group.

作者信息

Marchant C A

机构信息

LHASA UK, School of Chemistry, University of Leeds, United Kingdom.

出版信息

Environ Health Perspect. 1996 Oct;104 Suppl 5(Suppl 5):1065-73. doi: 10.1289/ehp.96104s51065.

DOI:10.1289/ehp.96104s51065
PMID:8933056
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1469697/
Abstract

DEREK is a knowledge-based expert system for the qualitative prediction of toxicity. The DEREK system has been used to predict the carcinogenicity in rodents of the 30 chemicals in the second National Toxicology Program (NTP) carcinogenicity prediction exercise. Seven of the chemicals were predicted to be carcinogens. For 23 chemicals, there was no evidence in the DEREK knowledge base to suggest carcinogenic activity. Supplementary data from a variety of sources have been evaluated by human experts to assess confidence in each DEREK prediction. These sources included standard toxicology reference texts, genotoxicity and subchronic toxicity assay results for each chemical, as well as Salmonella mutagenicity and carcinogenicity data for close structural analogues. This process has led to the proposal of a number of improvements to the DEREK carcinogenicity knowledge base.

摘要

DEREK是一个用于毒性定性预测的基于知识的专家系统。DEREK系统已被用于预测第二次国家毒理学计划（NTP）致癌性预测实验中30种化学物质在啮齿动物中的致癌性。其中7种化学物质被预测为致癌物。对于23种化学物质，DEREK知识库中没有证据表明其具有致癌活性。人类专家评估了来自各种来源的补充数据，以评估对每个DEREK预测的置信度。这些来源包括标准毒理学参考文本、每种化学物质的遗传毒性和亚慢性毒性试验结果，以及结构类似物的沙门氏菌诱变性和致癌性数据。这一过程导致了对DEREK致癌性知识库的一些改进建议。

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