van den Berg W B, van Lent P L
Department of Rheumatology, University Hospital Nijmegen, The Netherlands.
Immunobiology. 1996 Oct;195(4-5):614-23. doi: 10.1016/S0171-2985(96)80026-X.
Rheumatoid arthritis is characterized by a mononuclear infiltrate in the synovial tissue of the affected joints, considerable thickening of the synovial lining layer and concomitant destruction of cartilage and bone. Macrophages probably play a central role and the contribution of the synovial lining macrophages is addressed in studies in experimental murine arthritis models. Emphasis is given to the involvement in arthritis expression and cartilage destruction. The role of TNF-alpha and IL-1, and the modulatory cytokines IL-4/ IL-10 is briefly discussed.
类风湿性关节炎的特征是受累关节的滑膜组织中有单核细胞浸润、滑膜衬里层显著增厚以及伴随的软骨和骨破坏。巨噬细胞可能起核心作用，滑膜衬里巨噬细胞的作用在实验性小鼠关节炎模型研究中得到探讨。重点是其在关节炎表现和软骨破坏中的作用。简要讨论了肿瘤坏死因子-α和白细胞介素-1以及调节性细胞因子白细胞介素-4/白细胞介素-10的作用。
