Scheltens P, Barkhof F, Leys D, Pruvo J P, Nauta J J, Vermersch P, Steinling M, Valk J
Department of Neurology, Free University Hospital, Amsterdam, The Netherlands.
J Neurol Sci. 1993 Jan;114(1):7-12. doi: 10.1016/0022-510x(93)90041-v.
Differences in grading signal hyperintensities on magnetic resonance imaging may explain earlier reported conflicting results in studies of normal aging and dementia. We designed a new rating scale in which periventricular and white matter signal hyperintensities as well as basal ganglia and infratentorial signal hyperintensities are rated separately in a semiquantative way. In this study we compared the inter- and intra-observer agreements of this scale to the widely used rating scale of Fazekas. We confirmed the poor to reasonable intra- and inter-observer agreements of the Fazekas scale. The new scale, although more elaborate, provided good agreements with respect to the white matter, basal ganglia and infratentorial signal hyperintensities. In rating periventricular hyperintensities this scale yielded no advantage. It is concluded that this scale may be of use in studies especially focussing on deep white matter pathology on MRI, because it provides more detailed information, with good intra- and inter-observer reliability.
磁共振成像中信号高信号分级的差异可能解释了早期报道的正常衰老和痴呆研究中相互矛盾的结果。我们设计了一种新的评分量表，其中脑室周围和白质信号高信号以及基底神经节和幕下信号高信号以半定量方式分别进行评分。在本研究中，我们将该量表的观察者间和观察者内一致性与广泛使用的Fazekas评分量表进行了比较。我们证实了Fazekas量表的观察者内和观察者间一致性较差至合理。新量表虽然更详细，但在白质、基底神经节和幕下信号高信号方面具有良好的一致性。在对脑室周围高信号进行评分时，该量表没有优势。得出的结论是，该量表可能在特别关注MRI上深部白质病变的研究中有用，因为它提供了更详细的信息，具有良好的观察者内和观察者间可靠性。
