Blaustein J D, Wade G N
J Comp Physiol Psychol. 1977 Aug;91(4):752-60. doi: 10.1037/h0077365.
When a large dose of progesterone was administered to ovariectomized rats 24 hr after a 2-microgram injection of estradiol benzoate (EB), sexual receptivity was inhibited at 54 hr (sequential inhibition). Larger doses of progesterone (1 mg) were required to inhibit the induction of sexual receptivity when tested at 54 hr than were necessary to facilitate at 30 hr. This inhibition was not due to copulatory stimuli from the first test, because inhibition occurred even when the first test was omitted. The inhibition was dose dependent on estradiol; increasing the EB priming dose offset the inhibition caused by 1 mg of progesterone. The results of an experiment that dissociated behaviorally the antiestrogenic action of progesterone from that of a synthetic antiestrogen, CI-628, are consistent with the notion that progesterone and synthetic antiestrogens inhibit the neural effects of estradiol by separate mechanisms of action.
在给去卵巢大鼠注射2微克苯甲酸雌二醇（EB）24小时后给予大剂量孕酮，在54小时时性接受能力受到抑制（序贯抑制）。与在30小时时促进性接受能力相比，在54小时测试时需要更大剂量的孕酮（1毫克）来抑制性接受能力的诱导。这种抑制并非由于首次测试中的交配刺激，因为即使省略首次测试，抑制仍然会发生。这种抑制在剂量上依赖于雌二醇；增加EB预充剂量可抵消1毫克孕酮引起的抑制作用。一项从行为上区分孕酮与合成抗雌激素CI - 628抗雌激素作用的实验结果，与孕酮和合成抗雌激素通过不同作用机制抑制雌二醇神经效应的观点一致。
