Pedersen L M, Milman N
Department of Pulmonary Medicine, Gentofte Hospital, University of Copenhagen, Denmark.
Acta Oncol. 1996;35(6):691-5. doi: 10.3109/02841869609084000.
The purpose of the present study was to ascertain the prevalence and prognostic significance of proteinuria in patients with lung cancer. Results of urinary dipstick testing were retrospectively reviewed in 1026 consecutive out-patients with histologically proven primary lung cancer and 475 consecutive out-patients with benign pulmonary disorders. Postoperative urinary dipstick test results were recorded in 243 surgically resected patients. Proteinuria was significantly more frequent in patients with lung cancer than in controls (30.1% vs 8.8%, p < 0.0001). The presence of proteinuria was significantly correlated with advanced disease stage (p < 0.0001). The frequency of proteinuria was significantly higher in patients with small cell carcinoma than in patients with other histologic types (p < 0.01). In the surgically resected patients, preoperative and postresection proteinuria occurred in 25.5% and 10.7% respectively (p < 0.0001). Patients with malignancies and proteinuria had significantly poorer survival than patients with normal urinary protein excretion (p < 0.0001). In a multivariate analysis including TNM stage, histologic type, sex, and age, proteinuria continued to be a significant predictor of reduced survival time. Our results suggest a high prevalence of increased urinary protein excretion in patients with primary lung cancer. Proteinuria may also be an independent predictor of poor survival.
本研究的目的是确定肺癌患者蛋白尿的患病率及其预后意义。对1026例经组织学证实的原发性肺癌门诊患者和475例良性肺部疾病门诊患者的尿试纸检测结果进行了回顾性分析。记录了243例接受手术切除患者的术后尿试纸检测结果。肺癌患者蛋白尿的发生率显著高于对照组（30.1%对8.8%，p<0.0001）。蛋白尿的存在与疾病晚期显著相关（p<0.0001）。小细胞癌患者蛋白尿的发生率显著高于其他组织学类型的患者（p<0.01）。在接受手术切除的患者中，术前和术后蛋白尿的发生率分别为25.5%和10.7%（p<0.0001）。有恶性肿瘤和蛋白尿的患者生存率明显低于尿蛋白排泄正常的患者（p<0.0001）。在包括TNM分期、组织学类型、性别和年龄的多因素分析中，蛋白尿仍然是生存时间缩短的显著预测因素。我们的结果表明，原发性肺癌患者尿蛋白排泄增加的患病率很高。蛋白尿也可能是生存不良的独立预测因素。
