Chow E Y, Leung K K
Department of Pathology, Yan Chai Hospital, Hong Kong.
Clin Lab Haematol. 1996 Sep;18(3):187-93. doi: 10.1046/j.1365-2257.1996.00171.x.
The CELL-DYN 3500 (CD3500) (Abbott Diagnostics Division, Santa Clara, CA, USA) is a multiparameter, automated haematology analyser system capable of producing 22 haematological parameters including a screening five-part differential. The evaluation was performed in a recently expanded acute care general hospital. Studies of linearity, carryover and precision were acceptable and within manufacturer's stated limits. Correlation of CD3500 with manual differential counts were good except for the basophil count. The white cell flagging system had a sensitivity of 83.6% and specificity of 88.9% with 85.6% agreement. The platelet flagging system also had comparable sensitivity and specificity rate of 88.4% and 94.5% and agreement rate of 92.2%. The overall false positive rate and false negative rate for both the white cell and platelet flags combined were 8.6% and 10.3%. All samples provided a differential with no rejection experienced. The MAPSS technology, together with the extended lyse mode and the investigational nine-part differential provides potential for future development in WBC differential.
CELL-DYN 3500（CD3500）（美国加利福尼亚州圣克拉拉市雅培诊断部）是一款多参数自动血液分析仪系统，能够生成22项血液学参数，包括一项筛查性五分类白细胞计数。评估在一家近期扩建的急症综合医院进行。线性、携带污染和精密度研究结果均可接受，且在制造商规定的限度内。除嗜碱性粒细胞计数外，CD3500与手工分类计数的相关性良好。白细胞标记系统的灵敏度为83.6%，特异性为88.9%，符合率为85.6%。血小板标记系统的灵敏度和特异性分别为88.4%和94.5%，符合率为92.2%，也具有可比性。白细胞和血小板标记合并后的总体假阳性率和假阴性率分别为8.6%和10.3%。所有样本均提供了分类结果，未出现拒收情况。MAPSS技术，连同扩展裂解模式和研究性九分类白细胞计数，为白细胞分类的未来发展提供了潜力。
