Ridley A J
Ludwig Institute for Cancer Research London, UK.
Curr Biol. 1996 Oct 1;6(10):1256-64. doi: 10.1016/s0960-9822(02)70711-2.
In addition to their roles in organizing the actin cytoskeleton, members of the Rho family of GTP-binding proteins have recently been implicated in a plethora of other functions, including the activation of kinase cascades and transcription factors, and the control of endocytosis and secretion. Alongside this expansion is proposed functions has been the identification of multiple target proteins that interact directly with Rho, Rac or Cdc42. Molecular connections are now being made along the signalling pathways activated by members of the Rho family.
除了在组织肌动蛋白细胞骨架中发挥作用外，GTP结合蛋白Rho家族的成员最近还涉及许多其他功能，包括激酶级联反应和转录因子的激活，以及内吞作用和分泌的控制。随着其功能的扩展，已鉴定出多种与Rho、Rac或Cdc42直接相互作用的靶蛋白。目前正在Rho家族成员激活的信号通路中建立分子联系。
