桥粒：分化、发育、动态变化与疾病
Desmosomes: differentiation, development, dynamics and disease.
作者信息
Garrod D, Chidgey M, North A
机构信息
Epithelial Morphogenesis Research Group, School of Biological Sciences, University of Manchester, 3.239 Stopford Building, Oxford Road, Manchester M13 9PT, UK.
出版信息
Curr Opin Cell Biol. 1996 Oct;8(5):670-8. doi: 10.1016/s0955-0674(96)80108-6.
Recent evidence on the distribution of desmosomal glycoprotein isoforms that shows their combined expression in individual desmosomes has strengthened the belief that the latter are involved in epithelial differentiation and morphogenesis. It has been shown that cellular interactions and protein kinase C can modulate the adhesive properties of desmosomes in epithelial cell sheets. Genetic studies indicate the involvement of desmosomal components in cancer and epidermal diseases.
近期有关桥粒糖蛋白异构体分布的证据表明，它们在单个桥粒中共同表达，这强化了人们对于桥粒参与上皮分化和形态发生的信念。研究表明，细胞间相互作用和蛋白激酶C可调节上皮细胞片中桥粒的黏附特性。遗传学研究表明桥粒成分与癌症和表皮疾病有关。
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