Johnson Jodi L, Najor Nicole A, Green Kathleen J
Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
Cold Spring Harb Perspect Med. 2014 Nov 3;4(11):a015297. doi: 10.1101/cshperspect.a015297.
Desmosomes are intercellular junctions that mediate cell-cell adhesion and anchor the intermediate filament network to the plasma membrane, providing mechanical resilience to tissues such as the epidermis and heart. In addition to their critical roles in adhesion, desmosomal proteins are emerging as mediators of cell signaling important for proper cell and tissue functions. In this review we highlight what is known about desmosomal proteins regulating adhesion and signaling in healthy skin-in morphogenesis, differentiation and homeostasis, wound healing, and protection against environmental damage. We also discuss how human diseases that target desmosome molecules directly or interfere indirectly with these mechanical and signaling functions to contribute to pathogenesis.
桥粒是介导细胞间黏附并将中间丝网络锚定到质膜的细胞间连接，为表皮和心脏等组织提供机械弹性。除了在黏附中的关键作用外，桥粒蛋白正逐渐成为对细胞和组织正常功能至关重要的细胞信号传导介质。在这篇综述中，我们重点介绍了桥粒蛋白在健康皮肤中调节黏附和信号传导方面的已知情况——在形态发生、分化和稳态、伤口愈合以及抵御环境损伤方面。我们还讨论了直接靶向桥粒分子或间接干扰这些机械和信号功能从而导致发病机制的人类疾病。
