Kobayashi A, Ito M, Shiraishi H, Kishi K, Sejima H, Haneda N, Uchida N, Sugimura K
Department of Pediatrics, Shimane Medical University.
No To Hattatsu. 1996 Nov;28(6):501-7.
Single photon emission computed tomography (SPECT), using N-isopropyl-p-[123I] iodoamphetamine (123I-IMP) was used for quantitative analysis of regional cerebral blood flow (rCBF) on 26 individuals between 0 and 19 years of age. The rCBF showed age-related changes; it was low in early infancy, increased in late infancy through early childhood, and decreased and remained constant after puberty. The rCBF through cerebral cortex varied more greatly than through thalamus and cerebellum, and seemed to depend more closely on age. In the case of 4 months of age rCBF was very low at the frontal region and was very high at the occipital region. In more older cases, rCBF in the cerebral cortex was higher than in the thalamus. In childhood, rCBF was very inconsistent and showed a great inter-individual variance.
使用 N-异丙基-p-[123I] 碘安非他明（123I-IMP）的单光子发射计算机断层扫描（SPECT）用于对 26 名 0 至 19 岁个体的局部脑血流量（rCBF）进行定量分析。rCBF 呈现出与年龄相关的变化；在婴儿早期较低，在婴儿晚期至幼儿期增加，青春期后减少并保持稳定。通过大脑皮层的 rCBF 变化比通过丘脑和小脑的变化更大，并且似乎与年龄的关系更密切。在 4 个月大的情况下，额叶区域的 rCBF 非常低，枕叶区域的 rCBF 非常高。在年龄较大的个体中，大脑皮层的 rCBF 高于丘脑。在儿童期，rCBF 非常不稳定，个体间差异很大。
