Assali Mohyeddin, Zaid Abdel-Naser
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
Saudi Pharm J. 2022 Jan;30(1):53-65. doi: 10.1016/j.jsps.2021.12.018. Epub 2021 Dec 31.
Cosmeceuticals are a branch of cosmetic products that forms a bridge between cosmetic and drug products. It is a fast-growing branch of the cosmetic industry, especially after the introduction of novel formulation and manufacturing techniques such as lipid nanoparticles (LNPs). These LNPs-based cosmeceutical products offer several advantages such as enhanced bioavailability of cosmeceutical active ingredients (CAIs), improved aesthetic appeal, and stability of the final products. However, the use of these LNPs may raise some concerns about possible side effects of these LNPs and potential hazards to the customer's health. Accordingly, an update that focuses on the use of this important branch of nanoparticles is necessary since most review papers are dealing with all types of nanocarriers in the same review with little focus on LNPs. Therefore, in the current review, a detailed analysis of the advantages and disadvantages of LNPs in this field was highlighted, to emphasize the LNPs-based cosmeceuticals on the market, as well as the potential risk posed by LNPs on exposure and recently introduced regulatory guidelines to address them. In addition, if these products can be a candidate as products that meet the sustainable development goals raised by the UN are discussed.
药妆品是化妆品的一个分支，它在化妆品和药品之间架起了一座桥梁。它是化妆品行业中一个快速发展的分支，尤其是在引入脂质纳米颗粒（LNP）等新型配方和制造技术之后。这些基于LNP的药妆产品具有多种优势，如提高药妆活性成分（CAI）的生物利用度、改善美学吸引力以及提高最终产品的稳定性。然而，这些LNP的使用可能会引发一些关于其潜在副作用以及对消费者健康潜在危害的担忧。因此，有必要进行一次更新，重点关注这一重要的纳米颗粒分支的使用情况，因为大多数综述论文在同一篇综述中讨论所有类型的纳米载体，很少关注LNP。所以，在当前的综述中，突出了对LNP在该领域优缺点的详细分析，以强调市场上基于LNP的药妆品，以及LNP暴露带来的潜在风险和最近出台的应对这些风险的监管指南。此外，还讨论了这些产品是否可以成为符合联合国提出的可持续发展目标的产品候选。
