子宫内膜异位症患者腹水中干扰素γ产生减少及T淋巴细胞增殖受损。

Decrease in interferon gamma production and impairment of T-lymphocyte proliferation in peritoneal fluid of women with endometriosis.

作者信息

Ho H N, Wu M Y, Chao K H, Chen C D, Chen S U, Chen H F, Yang Y S

机构信息

Department of Obstetrics and Gynecology, College of Medicine and the Hospital, National Taiwan University, Taipei, Republic of China.

出版信息

Am J Obstet Gynecol. 1996 Nov;175(5):1236-41. doi: 10.1016/s0002-9378(96)70034-0.

DOI:10.1016/s0002-9378(96)70034-0

PMID:8942494

Abstract

OBJECTIVE

Our purpose was to verify regional immune modulations and to test the effect of gonadotropin-releasing hormone agonist in women with endometriosis.

STUDY DESIGN

Concentrations of peritoneal cytokines, including interleukin-1 beta, interleukin-2, soluble interleukin-2 receptor, interleukin-6, granulocyte-monocyte colony-stimulating factor, interferon gamma, and tumor necrosis factor-alpha were compared in women with and without endometriosis. Peritoneal cytokine and interleukin-2 production were examined by adding various mitogens to peritoneal fluid mononuclear cells of women with advanced endometriosis before and after gonadotropin-releasing hormone agonist treatment.

RESULTS

A significant increase in peritoneal interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha and a decrease in interferon gamma were noted in women with endometriosis. After gonadotropin-releasing hormone agonist treatment interleukin-6 decreased and interferon gamma increased. A significant impairment of interleukin-2 production of peritoneal fluid mononuclear cells by phytohemagglutinin and pokeweed mitogen stimulation was demonstrated in endometriosis, and production could be restored after gonadotropin-releasing hormone agonist treatment.

CONCLUSION

These results indicate that regional immunologic dysfunction might be invoked in the disease process of endometriosis.

摘要

目的

我们的目的是验证区域免疫调节作用，并测试促性腺激素释放激素激动剂对子宫内膜异位症女性的影响。

研究设计

比较有和没有子宫内膜异位症的女性腹腔细胞因子的浓度，包括白细胞介素-1β、白细胞介素-2、可溶性白细胞介素-2受体、白细胞介素-6、粒细胞-单核细胞集落刺激因子、干扰素γ和肿瘤坏死因子-α。在促性腺激素释放激素激动剂治疗前后，通过向晚期子宫内膜异位症女性的腹腔液单核细胞中添加各种丝裂原，检测腹腔细胞因子和白细胞介素-2的产生。

结果

子宫内膜异位症女性腹腔白细胞介素-1β、白细胞介素-6和肿瘤坏死因子-α显著增加，干扰素γ减少。促性腺激素释放激素激动剂治疗后，白细胞介素-6减少，干扰素γ增加。在子宫内膜异位症中，植物血凝素和商陆有丝分裂原刺激导致腹腔液单核细胞白细胞介素-2产生显著受损，促性腺激素释放激素激动剂治疗后产生可恢复。