Johnson G H, Baker D H, Perkins E G
J Nutr. 1977 Sep;107(9):1659-64. doi: 10.1093/jn/107.9.1659.
Fructose-phenylalanine, the Amadori compound resulting when glucose reacts with phenylalanine, was administered to chicks receiving a phenylalanine-deficient crystalline amino acid diet. The chicks did not respond to oral administration of this molecule which indicated it was nutritionally unavailable as a source of phenylalanine. In vitro protein synthesis studies on liver tissue showed that the rate of incorporation of 14C-phenylalanine into liver solids/mg tissue was significantly lower in chicks fed 0.404%-fructose-phenylalanine than in those not fed this compound. However, when fructose-phenylalanine was added directly to the incubation medium, no reduction of amino acid incorporation occurred. The discrepancy between in vitro and vivo results suggests, therefore, that fructose-phenylalanine is metabolized to another molecule which is causative in reducing liver protein synthesis.
果糖 - 苯丙氨酸是葡萄糖与苯丙氨酸反应生成的阿马多里化合物，将其给予食用缺乏苯丙氨酸的结晶氨基酸日粮的雏鸡。雏鸡对口服这种分子没有反应，这表明它作为苯丙氨酸来源在营养上无法利用。对肝脏组织进行的体外蛋白质合成研究表明，喂食0.404%果糖 - 苯丙氨酸的雏鸡中，每毫克组织中14C - 苯丙氨酸掺入肝脏固体的速率明显低于未喂食该化合物的雏鸡。然而，当将果糖 - 苯丙氨酸直接添加到孵育培养基中时，氨基酸掺入没有减少。因此，体外和体内结果之间的差异表明，果糖 - 苯丙氨酸被代谢为另一种分子，该分子导致肝脏蛋白质合成减少。
