Blazeby J M, Alderson D, Winstone K, Steyn R, Hammerlid E, Arraras J, Farndon J R
University Department of Surgery, Bristol Royal Infirmary, U.K.
Eur J Cancer. 1996 Oct;32A(11):1912-7. doi: 10.1016/0959-8049(96)00199-2.
Quality of life (QOL) assessments in patients with oesophageal cancer should provide clinically meaningful data that can assist management decision making. This study describes the development of a specific module for oesophageal cancer to use with the European Organisation into Research and Treatment of Cancer (EORTC) QOL questionnaire, the EORTC QLQ-C30. Relevant QOL issues were generated from a literature search and interviews with patients and oesophageal cancer specialists. Issues were formulated into items compatible with those of the EORTC QLQ-C30. The provisional module was pretested in patients from the United Kingdom, Spain and Sweden. The resulting module, the QLQ-OES 24, includes 24 items conceptualised as containing six scales and five single items. The addition of an oesophageal cancer-specific module to the core questionnaire should improve the sensitivity and specificity of the core instrument to allow detection of even small benefits accrued from new treatment modalities.
食管癌患者的生活质量（QOL）评估应提供具有临床意义的数据，以辅助管理决策。本研究描述了一个用于食管癌的特定模块的开发，该模块将与欧洲癌症研究与治疗组织（EORTC）生活质量问卷EORTC QLQ-C30一起使用。通过文献检索以及对患者和食管癌专家的访谈，确定了相关的生活质量问题。这些问题被编写成与EORTC QLQ-C30兼容的条目。该临时模块在来自英国、西班牙和瑞典的患者中进行了预测试。最终形成的模块QLQ-OES 24包括24个条目，概念化为包含六个量表和五个单项。在核心问卷中增加一个食管癌特异性模块应能提高核心工具的敏感性和特异性，以便检测出新治疗模式带来的哪怕是很小的益处。
