33例阿拉伯系统性红斑狼疮患者的临床实验室特征
Clinicolaboratory profile of 33 Arabs with systemic lupus erythematosus.
作者信息
al-Attia H M
机构信息
Department of Internal Medicine, Mafraq Hospital, Abu Dhabi, UAE.
出版信息
Postgrad Med J. 1996 Nov;72(853):677-9. doi: 10.1136/pgmj.72.853.677.
A clinical and laboratory survey of systemic lupus erythematosus was conducted in 33 Arab patients in the UAE. Arthropathy (91%) followed by renal involvement (54%) and haematological disorders (45.5%) were the major clinical manifestations. Discoid rash (3%) was the least common. Apart from headaches, other neuropsychiatric symptoms were uncommon or not encountered. A number of distinctive clinical subsets of lupus was also observed. An unusually high prevalence of dsDNA antibodies was detected in the study (97%), compared with a prevalence of 89.5% of ANF. There was a relative paucity of anti-Ro (18.5%), La (7.5%) and RNP (11%) antibodies, but a high rate of anti-Sm(33%). The occurrence of the latter in patients with central nervous system and renal disease was insignificant. C3-Hypocomplementaemia occurred in 38.5% of the patients and a positive VDRL and Coomb's test in 9% and 24%, respectively. This study provides additional information on the characterization of systemic lupus erythematosus in various populations.
对阿联酋的33名阿拉伯患者进行了系统性红斑狼疮的临床和实验室调查。关节病（91%）是主要临床表现，其次是肾脏受累（54%）和血液系统疾病（45.5%）。盘状红斑（3%）最为少见。除头痛外，其他神经精神症状并不常见或未出现。还观察到一些独特的狼疮临床亚型。研究中检测到dsDNA抗体的患病率异常高（97%），而抗核因子（ANF）的患病率为89.5%。抗Ro（18.5%）、La（7.5%）和核糖核蛋白（RNP，11%）抗体相对较少，但抗Sm抗体的比例较高（33%）。后者在中枢神经系统和肾脏疾病患者中的发生率无显著意义。38.5%的患者出现C3补体低下，9%的患者VDRL试验呈阳性，24%的患者库姆斯试验呈阳性。本研究为不同人群中系统性红斑狼疮的特征提供了更多信息。
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