Boey M L, Peebles C L, Tsay G, Feng P H, Tan E M
Department of Medicine IV, Tan Tock Seng Hospital, Singapore.
Ann Rheum Dis. 1988 Nov;47(11):918-23. doi: 10.1136/ard.47.11.918.
Serum samples from 94 patients with systemic lupus erythematosus (SLE) from a medical unit in Singapore were analysed for autoantibodies of 10 different specificities. The prevalence of antibodies to the following antigens was as follows: double stranded (ds) DNA (43%), histone (81%), Sm (26%), nuclear ribonuclear protein (nRNP) (32%), SS-A(Ro) (63%), SS-B(La) (12%), SL/Ki (9%), ribosomal RNP (rRNP) (16%), p70/p80 (5%), proliferating cell nuclear antigen (PCNA) (3%). Except for a higher prevalence of anti-SS-A(Ro), other autoantibodies were within the range reported from Western countries, indicating a high uniformity of autoantibody profiles in SLE in different countries. Patients with neuropsychiatric manifestations showed a higher plurality of antibodies per patient than patients without neuropsychiatric symptoms, 4.22 v 2.77. Patients with anti-Sm were more likely to have active lupus disease. There was no increased prevalence or specific type of autoantibody in those with renal manifestations.
对来自新加坡一个医疗单位的94例系统性红斑狼疮（SLE）患者的血清样本进行了10种不同特异性自身抗体的分析。以下抗原抗体的患病率如下：双链（ds）DNA（43%）、组蛋白（81%）、Sm（26%）、核核糖核蛋白（nRNP）（32%）、SS - A（Ro）（63%）、SS - B（La）（12%）、SL/Ki（9%）、核糖体RNP（rRNP）（16%）、p70/p80（5%）、增殖细胞核抗原（PCNA）（3%）。除了抗SS - A（Ro）的患病率较高外，其他自身抗体在西方国家报道的范围内，这表明不同国家SLE患者自身抗体谱具有高度一致性。有神经精神表现的患者每人的抗体种类比无神经精神症状的患者更多，分别为4.22种和2.77种。抗Sm抗体阳性的患者更易患活动性狼疮疾病。有肾脏表现的患者中自身抗体的患病率或特定类型并未增加。
