van Dusschoten D, Moonen C T, de Jager P A, Van As H
Agricultural University Wageningen, Department of Molecular Physics, The Netherlands.
Magn Reson Med. 1996 Dec;36(6):907-13. doi: 10.1002/mrm.1910360613.
A diffusion-weighted multi-spin-echo pulse sequence is presented, which allows for simultaneous measurement of T2, the fractional amplitude, and the diffusion constant of different fractions. Monte Carlo simulations demonstrate an improvement of this sequence with respect to the accuracy of diffusion constant and fractional amplitude for slow exchange. Examples are shown for a simple phantom containing two fractions. In addition, experiments on cat brain in healthy condition and following occlusion of the middle cerebral artery show that the fractional amplitude and the diffusion constant of cerebral spinal fluid and normal brain tissue can be analyzed within each pixel with acceptable accuracy.
本文提出了一种扩散加权多自旋回波脉冲序列，该序列能够同时测量T2、分数幅度以及不同组分的扩散常数。蒙特卡罗模拟表明，对于慢交换情况，该序列在扩散常数和分数幅度的准确性方面有所改进。给出了一个包含两种组分的简单模型的示例。此外，对健康猫脑以及大脑中动脉闭塞后的猫脑进行的实验表明，脑脊液和正常脑组织的分数幅度和扩散常数能够在每个像素内以可接受的准确性进行分析。
