Stanisz G J, Li J G, Wright G A, Henkelman R M
Imaging Research, Sunnybrook Health Science Centre, University of Torornto, Ontario, Canada.
Magn Reson Med. 1998 Feb;39(2):223-33. doi: 10.1002/mrm.1910390209.
An analytical model of tissue relaxation and restricted diffusion in human blood is presented. The blood tissue model is composed of three different compartments: red blood cells, plasma, and macromolecular protons. The relaxation rate constants and free diffusion coefficients of intracellular and extracellular water may differ. Analytical formulas for signal loss due to relaxation and diffusion in the Carr-Purcell Meiboom-Gill and pulsed-field-gradient multispin echo experiments for this tissue model are derived. The model is fitted to the experimental data for human blood with various concentrations of Gadolinium contrast agent. The obtained model parameters are realistic. The validity and sensitivity of the model are also discussed.
提出了一种人体血液中组织弛豫和受限扩散的分析模型。血液组织模型由三个不同的部分组成：红细胞、血浆和大分子质子。细胞内和细胞外水的弛豫速率常数和自由扩散系数可能不同。推导了该组织模型在Carr-Purcell Meiboom-Gill和脉冲场梯度多自旋回波实验中由于弛豫和扩散导致的信号损失的解析公式。该模型与不同浓度钆造影剂的人体血液实验数据进行拟合。所获得的模型参数是符合实际的。还讨论了该模型的有效性和敏感性。
