Whyte A C, Gloer J B, Wicklow D T, Dowdw P F
Department of Chemistry, University of Iowa, Iowa City 52242, USA.
J Nat Prod. 1996 Nov;59(11):1093-5. doi: 10.1021/np960607m.
Sclerotiamide (1), a new fungal natural product related to the paraherquamides, was isolated by bioassay-guided fractionation of antiinsectan organic extracts from the sclerotia of Aspergillus sclerotiorum (NRRL 5167). The structure was determined primarily through 1H-NMR, 13C-NMR, HMQC, and HMBC experiments. Sclerotiamide causes significant mortality and unusual physiological effects in dietary assays against the corn earworm Helicoverpa zea.
硬皮酰胺（1）是一种与副赫曲霉素相关的新型真菌天然产物，通过对来自核盘菌（NRRL 5167）菌核的抗昆虫有机提取物进行生物测定引导的分级分离而分离得到。其结构主要通过1H-NMR、13C-NMR、HMQC和HMBC实验确定。在针对玉米穗虫棉铃虫的饲料测定中，硬皮酰胺会导致显著的死亡率和异常的生理效应。
