Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Key Laboratory of Cosmetic, Beijing Technology and Business University, China National Light Industry, 33 Fucheng Road, Beijing 100048, China.
Mar Drugs. 2021 Mar 17;19(3):157. doi: 10.3390/md19030157.
Six new prenylated indole diketopiperazine alkaloids, asperthrins A-F (-), along with eight known analogues (-), were isolated from the marine-derived endophytic fungus sp. YJ191021. Their planar structures and absolute configurations were elucidated by HR-ESI-MS, 1D/2D NMR data, and time-dependent density functional theory (TDDFT)/ECD calculation. The isolated compounds were assayed for their inhibition against three agricultural pathogenic fungi, four fish pathogenic bacteria, and two agricultural pathogenic bacteria. Compound exhibited moderate antifungal and antibacterial activities against pv. , and with minimal inhibitory concentration (MIC) values of 8, 12.5, and 25 μg/mL, respectively. Furthermore, displayed notable anti-inflammatory activity with IC value of 1.46 ± 0.21 μM in induced human monocyte cell line (THP-1).
从海洋来源的内生真菌 sp. YJ191021 中分离得到了 6 种新的prenylated indole diketopiperazine 生物碱，asperthrins A-F (-)，以及 8 种已知类似物 (-)。通过高分辨电喷雾质谱 (HR-ESI-MS)、1D/2D NMR 数据和时变密度泛函理论 (TDDFT)/ECD 计算，确定了它们的平面结构和绝对构型。对分离得到的化合物进行了对三种农业病原菌、四种鱼类病原菌和两种农业病原菌的抑制活性测试。化合物 对 pv. 、 和 表现出中等的抗真菌和抗菌活性，MIC 值分别为 8、12.5 和 25 μg/mL。此外，化合物 在诱导的人单核细胞系 (THP-1) 中表现出显著的抗炎活性，IC 值为 1.46 ± 0.21 μM。
