对羟基赫曲霉素家族的其他新型代谢产物。
Further novel metabolites of the paraherquamide family.
作者信息
Blanchflower S E, Banks R M, Everett J R, Reading C
机构信息
SmithKline Beecham Animal Health, Tadworth, Surrey, England.
出版信息
J Antibiot (Tokyo). 1993 Sep;46(9):1355-63. doi: 10.7164/antibiotics.46.1355.
Four novel metabolites of a Penicillium strain, IMI 332995, which has previously been reported to produce paraherquamide and a number of related metabolites, are herein described. VM55596 is the first N-oxide to be found in this family of compounds. Unusual oxidative substitution is also seen in VM55597. VM55599 appears to be the first documented example of the hexacyclic indole species that have long been postulated as biosynthetic precursors of metabolites of the brevianamide, paraherquamide and marcfortine families.
青霉菌株IMI 332995的四种新代谢产物在此被描述，该菌株此前已被报道可产生对羟基赫曲霉素及一些相关代谢产物。VM55596是在该类化合物中首次发现的N-氧化物。在VM55597中还观察到了不寻常的氧化取代。VM55599似乎是六环吲哚类化合物的首个有文献记载的实例，长期以来人们一直假定该类化合物是短杆菌酰胺、对羟基赫曲霉素和马吲哚菌素家族代谢产物的生物合成前体。
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