Belofsky G N, Gloer K B, Gloer J B, Wicklow D T, Dowd P F
Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
J Nat Prod. 1998 Sep;61(9):1115-9. doi: 10.1021/np980188o.
Three new p-terphenyls (1-3), a new xanthone derivative (4), and two known fungal metabolites (5 and 6) have been isolated from the sclerotia of Penicillium raistrickii (NRRL 2039). The structures for 3,3"-dihydroxy-6'-desmethylterphenyllin (1); 3'-demethoxy-6'-desmethyl-5'-methoxycandidusin B (2); 6'-desmethylcandidusin B (3); and 1,3,5, 6-tetrahydroxy-8-methylxanthone (4) were determined on the basis of HRMS and NMR data. Although compounds 1 and 4 exhibited mild antiinsectan and antibacterial activity, griseofulvin (5) was responsible for most of the activity of the sclerotial extract in dietary assays against the corn earworm Helicoverpa zea.
从赖氏青霉（NRRL 2039）的菌核中分离出了三种新的对三联苯（1-3）、一种新的呫吨酮衍生物（4）以及两种已知的真菌代谢产物（5和6）。基于高分辨质谱（HRMS）和核磁共振（NMR）数据确定了3,3"-二羟基-6'-去甲基联苯双氢萘菌素（1）、3'-去甲氧基-6'-去甲基-5'-甲氧基念珠菌素B（2）、6'-去甲基念珠菌素B（3）以及1,3,5,6-四羟基-8-甲基呫吨酮（4）的结构。尽管化合物1和4表现出轻微的抗昆虫和抗菌活性，但在针对玉米穗虫烟青虫的饮食试验中，灰黄霉素（5）是菌核提取物大部分活性的原因。
