艾氏腹水瘤小鼠红细胞渗透脆性的改变

Altered erythrocyte osmotic fragility in mice with Ehrlich ascites tumor.

作者信息

Dumont A E, Nachbar M S, Martelli A B

出版信息

J Natl Cancer Inst. 1977 Sep;59(3):989-91. doi: 10.1093/jnci/59.3.989.

DOI:10.1093/jnci/59.3.989

Abstract

The osmotic fragility of erythrocytes from mice with Ehrlich ascites tumor was compared with that of erythrocytes from normal control animals. Erythrocytes collected from mice 15 days after the ip injection of tumor cells exhibited a uniform pattern of abnormal resistance to hemolysis in hypotonic saline, with 50% hemolysis occurring at an average saline concentration of 0.44% compared to an average of 0.49% for 11 controls a significant difference (P less than 0.0001). Erythrocytes from mice with this tumor apparently undergo an alteration in some component of the cell membrane that regulates either permeability to cations and water or distensibility of the cell.

摘要

将艾氏腹水瘤小鼠的红细胞渗透脆性与正常对照动物的红细胞渗透脆性进行了比较。在腹腔注射肿瘤细胞15天后从小鼠采集的红细胞，在低渗盐水中对溶血表现出一致的异常抗性模式，50%溶血发生时的平均盐水浓度为0.44%，而11只对照小鼠的平均浓度为0.49%，差异显著（P小于0.0001）。患有这种肿瘤的小鼠的红细胞显然在细胞膜的某些成分上发生了改变，这些成分调节对阳离子和水的通透性或细胞的扩张性。