de Argila Fernández-Aurán D, Revenga Arranz F, Iglesias Díez L
Servicio de Dermatología, Hospital Universitario Doce de Octubre, Madrid.
Rev Clin Esp. 1996 Jan;196(1):24-7.
Five patients with acral chilblains and lupus anticoagulant activity revealed by coagulation analysis are reported. Three patients suffered a systemic lupus erythematosus, and two of them a completely developed antiphospholipid syndrome as well. Another case had chronic cutaneous lupus with only facial discoid lesions, and in the last one the lupus anticoagulant was likely related to a chronic liver infection of hepatitis B virus because she had not erythematous lupus. There are few dermatologic references about chilblain associated to lupus anticoagulant. Certain evidences suggest a pathogenic relation of this findings.
报告了5例经凝血分析显示有肢端冻疮和狼疮抗凝活性的患者。3例患有系统性红斑狼疮，其中2例还完全发展为抗磷脂综合征。另一例患有仅面部有盘状皮损的慢性皮肤型狼疮，最后一例狼疮抗凝物可能与慢性乙型肝炎病毒感染有关，因为她没有红斑狼疮表现。关于与狼疮抗凝物相关的冻疮，皮肤科文献报道较少。某些证据提示了这一发现的致病关系。
