Berg R D
Dept of Microbiology and Immunology, Louisiana State University Medical Center, Shreveport 71106, USA.
Trends Microbiol. 1996 Nov;4(11):430-5. doi: 10.1016/0966-842x(96)10057-3.
The indigenous gastrointestinal (GI) tract microflora has profound effects on the anatomical, physiological and immunological development of the host. The indigenous microflora stimulates the host immune system to respond more quickly to pathogen challenge and, through bacterial antagonism, inhibits colonization of the GI tract by overt exogenous pathogens. Indigenous GI bacteria are also opportunistic pathogens and can translocate across the mucosal barrier to cause systemic infection in debilitated hosts.
肠道内的原生微生物群对宿主的解剖学、生理学和免疫学发育具有深远影响。原生微生物群刺激宿主免疫系统对病原体挑战做出更快反应，并通过细菌拮抗作用抑制明显的外源性病原体在胃肠道的定植。肠道原生细菌也是机会致病菌，可穿过黏膜屏障，在虚弱的宿主体内引起全身感染。
