Bertell R
J Surg Oncol. 1977;9(4):379-91. doi: 10.1002/jso.2930090409.
An hypothesis of an aging effect of exposure to ionizing radiation in humans is proposed and given precise mathematical expression. The assumption is made that the biological changes which occur when humans are exposed to ionizing radiation from medical x ray are comparable to those occuring through the natural aging process, since both factors are known to increase the relative risk of nonlymphatic leukemia. This assumption focuses on this one aspect of aging only. The hypothesis that aging and exposure to ionizing radiation are comparable for increasing the relative risk of non-lymphatic leukemia is tested against the data from the Tri-State Leukemia Survey. It is shown to explain the data in a statistically acceptable way, giving an estimate of 1 rad skin dose exposure to the trunk as comparable to 1 year natural aging. This research raises further questions concerning the effects of exposure to ionizing radiation, and presents a new methodology by which these questions may be researched.
提出了关于人类暴露于电离辐射的衰老效应假说，并给出了精确的数学表达式。假设人类在接受医用X射线电离辐射时发生的生物学变化与自然衰老过程中发生的变化相当，因为已知这两个因素都会增加非淋巴细胞白血病的相对风险。该假设仅关注衰老的这一个方面。针对三州白血病调查的数据，检验了衰老和暴露于电离辐射在增加非淋巴细胞白血病相对风险方面具有可比性的假说。结果表明，该假说能够以统计学上可接受的方式解释数据，估计躯干皮肤接受1拉德剂量的辐射相当于自然衰老1年。这项研究引发了关于电离辐射暴露影响的进一步问题，并提出了一种可用于研究这些问题的新方法。
