Ramos-Vara J A, Ortiz-Santiago B, Segalès J, Dunstan R W
Animal Health Diagnostic Laboratory, College of Veterinary Medicine, Michigan State University, East Lansing 48824, USA.
Vet Pathol. 1996 Nov;33(6):731-4. doi: 10.1177/030098589603300619.
This report contains the clinical, histologic, immunohistochemical, and electron microscopic findings in two cases of equine cutaneous leishmaniasis. Nodular, sometimes crusty or ulcerated lesions were confined to the pinna and adjacent neck in both animals. The dermal inflammatory infiltrate was lymphohistiocytic in horse No. 1 and pyogranulomatous with formation of tuberculoid granulomas in horse No. 2. Numerous Leishmania organisms were found within macrophages in both animals. There was moderate to intense and specific reaction by immunoperoxidase using a polyclonal antiserum against Leishmania in both horses. Leishmania amastigotes were also revealed by electron microscopy. This is the first report of equine cutaneous leishmaniasis recognized in North America and Puerto Rico. Leishmaniasis should be considered in the differential diagnosis of cutaneous nodular diseases in the horse.
本报告包含两例马皮肤利什曼病的临床、组织学、免疫组织化学和电子显微镜检查结果。两匹马的结节性病变，有时伴有结痂或溃疡，均局限于耳廓及相邻颈部。病例1的皮肤炎性浸润为淋巴细胞-组织细胞性，病例2为脓性肉芽肿性，并形成结核样肉芽肿。两匹马的巨噬细胞内均发现大量利什曼原虫。使用抗利什曼原虫多克隆抗血清进行免疫过氧化物酶检测，两匹马均出现中度至强阳性的特异性反应。电子显微镜检查也发现了利什曼无鞭毛体。这是北美和波多黎各首次报告马皮肤利什曼病。在马皮肤结节性疾病的鉴别诊断中应考虑利什曼病。
