Terai K, Matsuo A, McGeer E G, McGeer P L
Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, Canada.
Brain Res. 1996 Nov 11;739(1-2):343-9. doi: 10.1016/s0006-8993(96)01073-6.
The distribution of the nuclear factor-kappa B (NF-kappa B) was investigated immunohistochemically in recently infarcted areas of postmortem human brain. Previously we reported that immunoreactivity for NF-kappa B was enhanced in neurons of Alzheimer disease brain in comparison with control cases. In the present study, a similar enhancement of immunoreactivity was observed in glial cells of infarcted areas, but not in the unaffected surround. Prominent staining for NF-kappa B was seen in some astrocytes, particularly in the penumbra or border zone between ischemic and non-ischemic areas. In some cases, positively stained macrophages were also observed in affected areas. Capillary staining for NF-kappa B was weak and did not differ significantly between affected and unaffected areas. These results suggest that enhanced expression of astrocytic NF-kappa B occurs in cerebral infarcted areas.
采用免疫组织化学方法研究了人死后大脑近期梗死区域中核因子-κB（NF-κB）的分布情况。此前我们报道，与对照病例相比，阿尔茨海默病大脑神经元中NF-κB的免疫反应性增强。在本研究中，梗死区域的胶质细胞中观察到了类似的免疫反应性增强，但在未受影响的周围区域未观察到。在一些星形胶质细胞中可见NF-κB的显著染色，尤其是在缺血区和非缺血区之间的半暗带或边界区域。在某些情况下，在受影响区域也观察到了阳性染色的巨噬细胞。NF-κB的毛细血管染色较弱，且在受影响和未受影响区域之间无显著差异。这些结果表明，星形细胞NF-κB的表达增强发生在脑梗死区域。
