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产前乳酸铝暴露对大鼠条件性味觉厌恶和被动回避任务的影响。

Effect of prenatal aluminium lactate exposure on conditioned taste aversion and passive avoidance task in the rat.

作者信息

Gonda Z, Lehotzky K

机构信息

Eötvös University, Department of Comparative Physiology, Budapest, Hungary.

出版信息

J Appl Toxicol. 1996 Nov-Dec;16(6):529-32. doi: 10.1002/(SICI)1099-1263(199611)16:6<529::AID-JAT392>3.0.CO;2-S.

Abstract

Pregnant SPRD rats were injected s.c. daily with 2.45, 4.9 and 9.8 mg kg-1 aluminium lactate or distilled water on gestational days 7-15. Gestational aluminium treatment had no effect either on litter size or the body weight of pups on postnatal day 1 but it decreased postnatal weight gain resulting in significantly lower body weight at weaning (postnatal day 22). It had no effect on the acquisition of a conditioned taste aversion, but in a passive avoidance task the learning ability of pups of dams given the top dose of aluminium was impaired.

摘要

在妊娠第7至15天,每天给怀孕的SPRD大鼠皮下注射2.45、4.9和9.8毫克/千克乳酸铝或蒸馏水。孕期铝处理对产仔数或出生后第1天幼崽的体重没有影响,但它降低了出生后的体重增加,导致断奶时(出生后第22天)体重显著降低。它对条件性味觉厌恶的习得没有影响,但在被动回避任务中,给予最高剂量铝的母鼠所生幼崽的学习能力受损。

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