Carrier J, Monk T H, Buysse D J, Kupfer D J
Sleep and Chronobiology Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA.
Chronobiol Int. 1996 Nov;13(5):373-86. doi: 10.3109/07420529609012661.
This study examined the relationship between circadian temperature rhythm amplitude reduction and sleep consolidation parameters in a group of healthy elders experiencing a 6-h phase advance in routine. Twenty-five healthy old people (15 women, 10 men, 77-91 years old) lived in a time-isolation apartment. Throughout the study, subjects were instructed when to go to bed, get up, and take meals. The experiment started with 5 baseline days during which subjects were kept to a daily routine corresponding to their habitual sleep-wake cycle. The wake time of the 6th night was phase-advanced by 6 h and the routine for the remainder of the experiment was held constant at the new earlier phase position. Rectal temperature was recorded continuously and all sleep episodes recorded polygraphically. Time series of temperature data for each subject were analyzed by complex demodulation (CD). Five of the subjects were excluded from analysis because the percentage of variance accounted for by the remodulate was less than 55% for the postshift days and one subject was excluded because he showed an average sleep efficiency of less than 55% during baseline. In the remaining 19 subjects, the phase shift produced a large decrease of the mean amplitude of the temperature circadian rhythm (from 0.45 degree C to 0.25 degree C). During the first 3 nights following the phase shift, sleep efficiency was decreased and amount of wakefulness in the first half of the night (WFirst) was increased. No effect was found for the amount of wake in the second half of the night (WSecond). The change in amplitude of the temperature rhythm was significantly correlated with change in sleep efficiency (r = 0.5; p = 0.03) and with change in WFirst (r = -0.7; p < 0.001). There was no correlation between change in the amplitude of the temperature rhythm and WSecond. These results suggest that in older subjects, amplitude of the output of the circadian oscillator might indeed be involved in the sleep consolidation process but, in the first, rather than the second half of the night.
本研究调查了一组日常作息提前6小时的健康老年人的昼夜体温节律振幅降低与睡眠巩固参数之间的关系。25名健康老人（15名女性，10名男性，年龄77 - 91岁）居住在一个时间隔离公寓中。在整个研究过程中，指导受试者何时睡觉、起床和用餐。实验开始时有5天的基线期，在此期间受试者保持与其习惯的睡眠 - 觉醒周期相对应的日常作息。第6晚的起床时间提前6小时，实验剩余时间的日常作息在新的较早阶段保持不变。连续记录直肠温度，并通过多导睡眠图记录所有睡眠阶段。通过复解调（CD）分析每个受试者的温度数据时间序列。5名受试者被排除在分析之外，因为在 shift 后几天，重新调制所解释的方差百分比小于55%，还有1名受试者被排除，因为他在基线期的平均睡眠效率低于55%。在其余19名受试者中，相位偏移导致体温昼夜节律的平均振幅大幅下降（从0.45摄氏度降至0.25摄氏度）。在相位偏移后的前3个晚上，睡眠效率降低，上半夜的清醒时间（WFirst）增加。下半夜的清醒时间（WSecond）未发现影响。温度节律振幅的变化与睡眠效率的变化显著相关（r = 0.5；p = 0.03），与WFirst的变化显著相关（r = -0.7；p < 0.001）。温度节律振幅的变化与WSecond之间没有相关性。这些结果表明，在老年受试者中，昼夜振荡器输出的振幅可能确实参与了睡眠巩固过程，但主要是在上半夜，而非下半夜。
