Gardner D G
Division of Oral Pathology and Oncology, University of Colorado School of Dentistry, Denver, USA.
Oral Dis. 1996 Jun;2(2):148-54. doi: 10.1111/j.1601-0825.1996.tb00216.x.
Spontaneous squamous cell carcinomas of the oral region in domestic animals have the potential of providing additional information about the pathology of oral cancer and may be useful in therapeutic research. Moreover, they exhibit definite advantages over chemically induced tumors in rodents. This article provides background information on spontaneous oral squamous cell carcinomas in dogs, cats, cattle, horses and sheep and then discusses the use in research of such tumors in dogs and cats. These two species are potentially the most useful because they are numerous, suffer quite commonly from squamous cell carcinoma of the oral cavity and oropharynx, and are usually allowed to live approximately normal life spans. Moreover, they are being treated routinely in veterinary hospitals.
家畜口腔区域的自发性鳞状细胞癌有可能提供有关口腔癌病理学的更多信息，并且可能在治疗研究中有用。此外，它们相对于啮齿动物化学诱导的肿瘤具有明显优势。本文提供了关于犬、猫、牛、马和羊自发性口腔鳞状细胞癌的背景信息，然后讨论了此类肿瘤在犬和猫研究中的应用。这两个物种可能是最有用的，因为它们数量众多，口腔和口咽鳞状细胞癌相当常见，并且通常能活到接近正常寿命。此外，它们在兽医医院接受常规治疗。
