Liccardi G, Salzillo A, Noschese P, Piccolo A, Calderaro F, D'Amato M, D'Amato G
Department of Chest Diseases, Hospital A. Cardarelli, Naples, Italy.
J Investig Allergol Clin Immunol. 1996 Sep-Oct;6(5):283-7.
The aim of our study was the evaluation of the clinical significance of allergic sensitization to cockroaches (C) in subjects with skin prick test (SPT) positivity only to mites, since we previously demonstrated a frequent association of SPT positivity between the allergens of these parasites. We studied 231 patients with mite related respiratory symptoms and living in the Naples area in order to obtain a highly homogeneous sample. All patients underwent anamnestic procedures, physical examination, SPT by using commercially available materials and an extract containing the whole bodies of three C. Specific C IgE assays were carried out only in C SPT positive patients. 34 of 231 subjects showed a SPT positivity to C allergens with a moderate/low degree of SPT responses and serum specific IgE levels. The results of this study confirm our previous report on the slight role of C as sensitizing agents of the respiratory tract in Southern Italy. Further studies should be carried out in subjects with a higher risk of environmental exposure by using better purified and standardized allergenic extracts. We suggest moreover to perform in vivo and in vitro diagnostic tests for C allergens in patients with perennial symptoms, especially in those with slight response to therapy, or potentially exposed to allergens of these insects.
我们研究的目的是评估仅对螨虫皮肤点刺试验（SPT）呈阳性的受试者中对蟑螂（C）过敏致敏的临床意义，因为我们之前证明了这些寄生虫过敏原之间SPT阳性的频繁关联。我们研究了231名居住在那不勒斯地区、有螨虫相关呼吸道症状的患者，以便获得一个高度同质的样本。所有患者都接受了问诊程序、体格检查、使用市售材料进行的SPT以及一种含有三种蟑螂完整身体的提取物的检测。仅对蟑螂SPT阳性的患者进行了特异性蟑螂IgE检测。231名受试者中有34名对蟑螂过敏原的SPT呈阳性，SPT反应程度为中度/低度，血清特异性IgE水平也如此。本研究结果证实了我们之前关于蟑螂在意大利南部作为呼吸道致敏原作用轻微的报告。应使用更好纯化和标准化的变应原提取物，对环境暴露风险较高的受试者进行进一步研究。此外，我们建议对常年有症状的患者，尤其是对治疗反应轻微或可能接触这些昆虫过敏原的患者，进行蟑螂过敏原的体内和体外诊断检测。
