von Birgelen C, van der Lugt A, Nicosia A, Mintz G S, Gussenhoven E J, de Vrey E, Mallus M T, Roelandt J R, Serruys P W, de Feyter P J
Thoraxcenter, University Hospital Rotterdam-Dijkzigt, Erasmus University, Rotterdam, The Netherlands.
Am J Cardiol. 1996 Dec 1;78(11):1202-9. doi: 10.1016/s0002-9149(96)00596-6.
Intravascular ultrasound (IVUS), which depicts both lumen and plaque, offers the potential to improve on the limitations of angiography for the assessment of the natural history of atherosclerosis and progression or regression of the disease. To facilitate measurements and increase the reproducibility of quantitative IVUS analyses, a computerized contour detection system was developed that detects both the luminal and external vessel boundaries in 3-dimensional sets of IVUS images. To validate this system, atherosclerotic human coronary segments (n = 13) with an area obstruction > or = 40% (40% to 61%) were studied in vitro by IVUS. The computerized IVUS measurements (areas and volumes) of the lumen, total vessel, plaque-media complex, and percent obstruction were compared with findings by manual tracing of the IVUS images and of the corresponding histologic cross sections obtained at 2-mm increments (n = 100). Both area and volume measurements by the contour detection system agreed well with the results obtained by manual tracing, showing low mean between-method differences (-3.7% to 0.3%) with SDs not exceeding 6% and high correlation coefficients (r = 0.97 to 0.99). Measurements of the lumen, total vessel, plaque-media complex, and percent obstruction by the contour detection system correlated well with histomorphometry of areas (r = 0.94, 0.88, 0.80, and 0.88) and volumes (r = 0.98, 0.91, 0.83, and 0.91). Systematic differences between the results by the contour detection system and histomorphometry (29%, 13%, -9%, and -22%, respectively) were found, most likely resulting from shrinkage during tissue fixation. The results of this study indicate that this computerized IVUS analysis system is reliable for the assessment of coronary atherosclerosis in vivo.
血管内超声（IVUS）能够同时显示管腔和斑块，为改善血管造影在评估动脉粥样硬化自然病程及疾病进展或消退方面的局限性提供了可能。为便于测量并提高定量IVUS分析的可重复性，开发了一种计算机化轮廓检测系统，该系统可在IVUS图像的三维数据集中检测管腔和血管外边界。为验证该系统，对13段面积阻塞≥40%（40%至61%）的人类动脉粥样硬化冠状动脉节段进行了体外IVUS研究。将计算机化IVUS测量的管腔、总血管、斑块-中膜复合体面积和体积以及阻塞百分比与通过手动描绘IVUS图像及以2毫米增量获取的相应组织学横截面（n = 100）的结果进行比较。轮廓检测系统的面积和体积测量结果与手动描绘结果高度一致，方法间平均差异较低（-3.7%至0.3%），标准差不超过6%，相关系数较高（r = 0.97至0.99）。轮廓检测系统测量的管腔、总血管、斑块-中膜复合体面积和体积以及阻塞百分比与区域组织形态计量学（r = 0.94、0.88、0.80和0.88）和体积（r = 0.98、0.91、0.83和0.91）具有良好的相关性。发现轮廓检测系统结果与组织形态计量学之间存在系统性差异（分别为29%、13%、-9%和-22%），最可能是由于组织固定过程中的收缩所致。本研究结果表明，这种计算机化IVUS分析系统在体内评估冠状动脉粥样硬化方面是可靠的。
