多结构域和多组分蛋白质系统的对称性、稳定性及动力学
Symmetry, stability, and dynamics of multidomain and multicomponent protein systems.
作者信息
Blundell T L, Srinivasan N
机构信息
Department of Biochemistry, University of Cambridge, United Kingdom.
出版信息
Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14243-8. doi: 10.1073/pnas.93.25.14243.
Abstract
Symmetry is commonly observed in many biological systems. Here we discuss representative examples of the role of symmetry in structural molecular biology. Point group symmetries are observed in many protein oligomers whose three-dimensional atomic structures have been elucidated by x-ray crystallography. Approximate symmetry also occurs in multidomain proteins. Symmetry often confers stability on the molecular system and results in economical usage of basic components to build the macromolecular structure. Symmetry is also associated with cooperativity. Mild perturbation from perfect symmetry may be essential in some systems for dynamic functions.
摘要
对称性在许多生物系统中普遍存在。在此，我们讨论对称性在结构分子生物学中作用的代表性例子。在许多蛋白质寡聚体中观察到点群对称性，其三维原子结构已通过X射线晶体学阐明。多结构域蛋白质中也存在近似对称性。对称性通常赋予分子系统稳定性，并导致构建大分子结构时基本组件的经济使用。对称性还与协同性相关。在某些系统中，对于动态功能而言，与完美对称性的轻微偏差可能至关重要。
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本文引用的文献
1
Protein disk of tobacco mosaic virus at 2.8 A resolution showing the interactions within and between subunits.烟草花叶病毒蛋白质盘，分辨率为2.8埃，展示了亚基内部及亚基之间的相互作用。
Nature. 1978 Nov 23;276(5686):362-8. doi: 10.1038/276362a0.
2
ATP induces large quaternary rearrangements in a cage-like chaperonin structure.三磷酸腺苷（ATP）会在笼状伴侣蛋白结构中引发大规模的四级重排。
Curr Biol. 1993 May 1;3(5):265-73. doi: 10.1016/0960-9822(93)90176-o.
3
Refined structure of concanavalin A complexed with methyl alpha-D-mannopyranoside at 2.0 A resolution and comparison with the saccharide-free structure.伴刀豆球蛋白A与α-D-甲基甘露糖苷复合物在2.0埃分辨率下的精细结构及其与无糖类结构的比较。
Acta Crystallogr D Biol Crystallogr. 1994 Nov 1;50(Pt 6):847-58. doi: 10.1107/S0907444994005287.
4
Physical principles in the construction of regular viruses.常规病毒构建中的物理原理。
Cold Spring Harb Symp Quant Biol. 1962;27:1-24. doi: 10.1101/sqb.1962.027.001.005.
5
Structure of small viruses.小型病毒的结构
Nature. 1956 Mar 10;177(4506):473-5. doi: 10.1038/177473a0.
6
Crystal structure of a new heat-labile enterotoxin, LT-IIb.新型不耐热肠毒素LT-IIb的晶体结构
Structure. 1996 Jun 15;4(6):665-78. doi: 10.1016/s0969-2126(96)00073-1.
7
Circular assemblies.圆形组件。
Curr Opin Struct Biol. 1996 Apr;6(2):142-50. doi: 10.1016/s0959-440x(96)80067-4.
8
Conformation, protein-carbohydrate interactions and a novel subunit association in the refined structure of peanut lectin-lactose complex.花生凝集素-乳糖复合物精细结构中的构象、蛋白质-碳水化合物相互作用及一种新型亚基缔合
J Mol Biol. 1996 Jun 7;259(2):281-96. doi: 10.1006/jmbi.1996.0319.
9
Three dimensional structure of human C-reactive protein.人类C反应蛋白的三维结构
Nat Struct Biol. 1996 Apr;3(4):346-54. doi: 10.1038/nsb0496-346.
10
Protein structure. Why have six-fold symmetry?
Curr Biol. 1995 Nov 1;5(11):1239-42. doi: 10.1016/s0960-9822(95)00247-8.
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