Wolynes P G
School of Chemical Sciences, University of Illinois, Urbana-Champaign 61801, USA.
Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14249-55. doi: 10.1073/pnas.93.25.14249.
The role of symmetry in the folding of proteins is discussed using energy landscape theory. An analytical argument shows it is much easier to find sequences with funneled energy landscape capable of fast folding if the structure is symmetric. The analogy with phase transitions of small clusters with magic numbers is discussed.
利用能量景观理论探讨了对称性在蛋白质折叠中的作用。一个分析论证表明，如果结构是对称的，那么找到具有能够快速折叠的漏斗状能量景观的序列要容易得多。文中还讨论了与具有幻数的小簇的相变之间的类比。
