Buckner R L, Bandettini P A, O'Craven K M, Savoy R L, Petersen S E, Raichle M E, Rosen B R
Department of Radiology, Massachusetts General Hospital Nuclear Magnetic Resonance Center, Charlestown 02129, USA.
Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14878-83. doi: 10.1073/pnas.93.25.14878.
Functional neuroimaging studies in human subjects using positron emission tomography or functional magnetic resonance imaging (fMRI) are typically conducted by collecting data over extended time periods that contain many similar trials of a task. Here methods for acquiring fMRI data from single trials of a cognitive task are reported. In experiment one, whole brain fMRI was used to reliably detect single-trial responses in a prefrontal region within single subjects. In experiment two, higher temporal sampling of a more limited spatial field was used to measure temporal offsets between regions. Activation maps produced solely from the single-trial data were comparable to those produced from blocked runs. These findings suggest that single-trial paradigms will be able to exploit the high temporal resolution of fMRI. Such paradigms will provide experimental flexibility and time-resolved data for individual brain regions on a trial-by-trial basis.
在人类受试者中使用正电子发射断层扫描或功能磁共振成像（fMRI）进行的功能性神经成像研究，通常是通过在包含许多类似任务试验的较长时间段内收集数据来进行的。本文报告了从认知任务的单次试验中获取fMRI数据的方法。在实验一中，全脑fMRI被用于可靠地检测单个受试者前额叶区域内的单次试验反应。在实验二中，对更有限的空间区域进行了更高时间分辨率的采样，以测量不同区域之间的时间偏移。仅从单次试验数据生成的激活图与从组块设计运行生成的激活图相当。这些发现表明，单次试验范式将能够利用fMRI的高时间分辨率。这种范式将在逐次试验的基础上为各个脑区提供实验灵活性和时间分辨数据。
