Makiyama K, Takuma K, Zea-Iriarte W L, Ikuno N, Kawatomi M, Mori N, Ishino T, Yonemitsu N
Department of Internal Medicine, Hokusho Central Hospital, Nagasaki, Japan.
J Gastroenterol. 1995 Dec;30(6):798-802. doi: 10.1007/BF02349652.
A 58-year-old Japanese man was admitted complaining of abdominal pain. An abdominal computed tomography examination demonstrated a tumor in the head of the pancreas and multiple calcifications. A laparotomy was performed and the tumor was removed by Whipple's operation. Histologically, the neoplasm that invaded the duodenal wall and the papilla of Vater was composed of nests of malignant squamous cells with intercellular bridges and showed the formation of keratinized pearls with a small area of concurrently neoplastic glandular and squamous elements. On the basis of these features, the diagnosis of adenosquamous carcinoma of the pancreas was made. The patient died 18 months after the operation. The neoplastic behavior of this rare primary pancreatic carcinoma is similar to that of duct cell carcinoma as well as pure squamous cell carcinoma of the pancreas. As the pancreas can be the target of metastases of squamous carcinomas from other organs it is wise to be aware of this rare entity.
一名58岁的日本男性因腹痛入院。腹部计算机断层扫描检查显示胰头有一个肿瘤和多处钙化。进行了剖腹手术，并通过惠普尔手术切除了肿瘤。组织学上，侵犯十二指肠壁和 Vater 乳头的肿瘤由具有细胞间桥的恶性鳞状细胞巢组成，并显示有角化珠形成，同时有小面积的肿瘤性腺样和鳞状成分。基于这些特征，诊断为胰腺腺鳞癌。患者术后18个月死亡。这种罕见的原发性胰腺癌的肿瘤行为与胰腺导管细胞癌以及胰腺纯鳞状细胞癌相似。由于胰腺可能是其他器官鳞状癌转移的靶器官，因此了解这种罕见的实体是明智的。
