den Otter W, Merchant T E, Beijerinck D, Koten J W
Department of Pathology, University of Utrecht, The Netherlands.
Anticancer Res. 1993 Jul-Aug;13(4):1113-5.
In this paper we present our view on the contribution of mammography examinations to breast cancer induction in patients with hereditary breast cancer predisposition. We contradict the usual reasoning that the benefits of early breast cancer detection outweigh the small number of induced breast cancers. Though this tenet is justified in the majority of women, yet in a small, readily identifiable group of hereditary effected women, radiation even in small doses may enhance oncogenesis. If this relatively small group of patients is barred from mammography and regularly screened with other means, mammography may even become a more safe procedure.
在本文中,我们阐述了对于乳腺钼靶检查在遗传性乳腺癌易感患者中诱发乳腺癌作用的观点。我们反对那种认为早期乳腺癌检测的益处大于少量诱发乳腺癌病例的常见观点。尽管这一原则在大多数女性中是合理的,但在一小部分易于识别的遗传性受影响女性中,即使是小剂量辐射也可能促进肿瘤发生。如果将这一相对较小的患者群体排除在钼靶检查之外,并通过其他方法进行定期筛查,那么钼靶检查甚至可能成为一种更安全的检查手段。