Galán J E, Bliska J B
Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook 11794-5222, USA.
Annu Rev Cell Dev Biol. 1996;12:221-55. doi: 10.1146/annurev.cellbio.12.1.221.
A taxonomically diverse group of bacterial pathogens have evolved a variety of strategies to subvert host-cellular functions to their advantage. This often involves two-way biochemical interactions leading to responses in both the pathogen and host cell. Central to this interaction is the function of a specialized protein secretion system that directs the export and/or translocation into the host cells of a number of bacterial proteins that can induce or interfere with host-cell signal transduction pathways. The understanding of these bacterial/host-cell interactions will not only lead to novel therapeutic approaches but will also result in a better understanding of a variety of basic aspects of cell physiology and immunology.
一大类分类学上多样的细菌病原体已经进化出各种策略，以将宿主细胞功能颠覆为对它们有利的状态。这通常涉及双向生化相互作用，导致病原体和宿主细胞都产生反应。这种相互作用的核心是一种特殊蛋白质分泌系统的功能，该系统将多种能够诱导或干扰宿主细胞信号转导途径的细菌蛋白质输出和/或转运到宿主细胞中。对这些细菌/宿主细胞相互作用的理解不仅将带来新的治疗方法，还将有助于更好地理解细胞生理学和免疫学的各种基本方面。
