非洲猪瘟病毒中mRNA的中间类别。
Intermediate class of mRNAs in African swine fever virus.
作者信息
Rodríguez J M, Salas M L, Viñuela E
机构信息
Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid), Facultadde Ciencias, Cantoblanco, Spain.
出版信息
J Virol. 1996 Dec;70(12):8584-9. doi: 10.1128/JVI.70.12.8584-8589.1996.
Abstract
A transcriptional analysis of the African swine fever virus (ASFV) I226R and I243L genes is presented. Steady-state kinetics and transfection experiments showed the existence of a new temporal class of ASFV mRNAs transcribed from these genes, with the characteristics of the poxvirus intermediate transcripts. Transcription of the I226R gene gave rise to intermediate and late mRNAs that started from different sites, while the I243L gene produced early, intermediate, and late mRNAs, also starting from different sites. The presence of intermediate genes suggests a cascade model for the regulation of ASFV gene expression.
摘要
本文对非洲猪瘟病毒（ASFV）的I226R和I243L基因进行了转录分析。稳态动力学和转染实验表明，从这些基因转录出的ASFV mRNA存在一种新的时间类别，具有痘病毒中间转录本的特征。I226R基因的转录产生了起始于不同位点的中间和晚期mRNA，而I243L基因也产生了起始于不同位点的早期、中间和晚期mRNA。中间基因的存在提示了ASFV基因表达调控的级联模型。
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