Lin B T, Chen Y Y, Battifora H, Weiss L M
Division of Pathology, City of Hope National Medical Center, Duarte, California 91010, USA.
Mod Pathol. 1996 Dec;9(12):1143-6.
Reports connect Kaposi's sarcoma-associated herpesvirus (KSHV) with various types of Kaposi's sarcoma (KS) and body-cavity-based lymphomas (primary effusion lymphomas). KSHV DNA sequences have also been detected in a few non-KS malignant vascular tumors. To determine whether KSHV is associated with malignant vascular tumors involving the body cavities, 11 primary vascular tumors of the serous membranes (4 angiosarcomas, 7 hemangioendotheliomas) were tested for KSHV sequences by polymerase chain reaction and Southern blot hybridization. The tumors were from patients who were not known to be immunocompromised. KSHV sequences were detected in the penile KS control but were absent in all 11 specimens studied. Our results were consistent with previous reports that KSHV sequences were rarely detected in non-KS vascular lesions. The results also suggested that although KSHV sequences might be present in primary effusion tumors such as primary effusion lymphoma, they might not be found in other tumors related to body cavities or to serous membranes.
报告显示卡波西肉瘤相关疱疹病毒（KSHV）与多种类型的卡波西肉瘤（KS）及体腔淋巴瘤（原发性渗出性淋巴瘤）有关。在一些非KS恶性血管肿瘤中也检测到了KSHV DNA序列。为了确定KSHV是否与累及体腔的恶性血管肿瘤有关，采用聚合酶链反应和Southern印迹杂交技术对11例原发性浆膜血管肿瘤（4例血管肉瘤，7例血管内皮瘤）进行了KSHV序列检测。这些肿瘤来自未知免疫功能低下的患者。在阴茎KS对照中检测到KSHV序列，但在所研究的所有11个标本中均未检测到。我们的结果与先前的报告一致，即在非KS血管病变中很少检测到KSHV序列。结果还表明，虽然KSHV序列可能存在于原发性渗出性肿瘤如原发性渗出性淋巴瘤中，但在其他与体腔或浆膜相关的肿瘤中可能无法发现。
