Kang G H, Kwon G Y, Kim C W
Asan Medical Center, Ulsan University College of Medicine, Department of Pathology, Seoul, Korea.
J Korean Med Sci. 1998 Feb;13(1):54-9. doi: 10.3346/jkms.1998.13.1.54.
Kaposi's sarcoma (KS) had been a rare and unusual vascular tumor until a recent epidemic of a disseminated and fulminant form of KS in AIDS patients. Infectious agents have been suspected of causing KS, and recently partial genomic DNA sequences of human herpesvirus 8 (HHV8) have been identified in AIDS-associated KS lesions. Since then, genomic DNA sequences of HHV8 have been isolated in other forms of KS. Although the partial genomic DNA sequence of HHV8 was reported to be, if rare, identified in vascular tumors other than Kaposi's sarcoma (KS), the presence of HHV8 in a very large fraction of KS indicates that detection of HHV8 by PCR is a useful auxiliary tool in differentiating KS from other KS-mimicking vascular tumors. We examined whether the 233-bp segment of the viral DNA was detected in Korean patients with KS and other KS-mimicking vascular tumors. HHV8 sequences were identified in all of nine classic type of KS but not in three epithelioid hemangioendotheliomas and seven angiosarcomas. Our results confirm the relatively restricted distribution of HHV8 and also argue against the likelihood of secondary colonization of KS cells by HHV8.
卡波西肉瘤（KS）曾是一种罕见且特殊的血管肿瘤，直到近期艾滋病患者中出现了一种播散性暴发性KS的流行情况。人们怀疑感染因子可导致KS，最近在艾滋病相关KS病变中已鉴定出人类疱疹病毒8（HHV8）的部分基因组DNA序列。从那时起，HHV8的基因组DNA序列已在其他形式的KS中分离出来。尽管有报道称，在卡波西肉瘤（KS）以外的血管肿瘤中，HHV8的部分基因组DNA序列即便罕见也能被鉴定出来，但在很大一部分KS中存在HHV8表明，通过聚合酶链反应（PCR）检测HHV8是区分KS与其他类似KS的血管肿瘤的有用辅助工具。我们检测了在韩国KS患者及其他类似KS的血管肿瘤患者中是否能检测到病毒DNA的233碱基对片段。在所有9例经典型KS中均鉴定出HHV8序列，但在3例上皮样血管内皮瘤和7例血管肉瘤中未检测到。我们的结果证实了HHV8分布相对受限，也反驳了HHV8对KS细胞进行二次定植的可能性。
