Ascoli V, Nardi F, Carnovale Scalzo C, Signoretti S, Pistilli A, Lo Coco F
Dipartimento di Medicina Sperimentale e Patologia, Università La Sapienza, Rome, Italy.
Mol Pathol. 1998 Apr;51(2):113-4. doi: 10.1136/mp.51.2.113.
Human herpesvirus 8 (HHV-8) associated primary effusion lymphomas arise and grow in the body cavities as effusions, but it is not known whether the lining of body cavities and mesothelium derived malignancies are potential targets of HHV-8 infection. We examined a series of 13 diffuse malignant mesotheliomas and four mesothelial cell rich effusion samples of non-neoplastic aetiology from non-immunodepressed patients using the polymerase chain reaction to detect HHV-8 specific sequences. HHV-8 amplification products were absent in diffuse malignant mesotheliomas and in non-neoplastic effusions samples. These results suggest that HHV-8 has a selective tropism among body cavity based tumours, being confined to primary effusion lymphomas.
人类疱疹病毒8型（HHV-8）相关的原发性渗出性淋巴瘤在体腔内以渗出液的形式发生和生长，但目前尚不清楚体腔内膜和间皮来源的恶性肿瘤是否是HHV-8感染的潜在靶点。我们使用聚合酶链反应检测HHV-8特异性序列，对13例弥漫性恶性间皮瘤以及来自非免疫抑制患者的4例非肿瘤病因的富含间皮细胞的渗出液样本进行了研究。弥漫性恶性间皮瘤和非肿瘤性渗出液样本中均未出现HHV-8扩增产物。这些结果表明，HHV-8在基于体腔的肿瘤中具有选择性嗜性，仅限于原发性渗出性淋巴瘤。
