Morgan D S, Fisher D, Merianos A, Currie B J
Division of Medicine, Royal Darwin Hospital, Northern Territory, Australia.
Epidemiol Infect. 1996 Dec;117(3):423-8. doi: 10.1017/s0950268800059070.
A retrospective study of 191 cases of septic arthritis was undertaken at Royal Darwin Hospital in the tropical north of Australia. Incidence was 9.2 per 100,000 overall and 29.1 per 100,000 in Aboriginal Australians (RR 6.6; 95% CI 5.0-8.9). Males were affected more than females (RR 1.6; 95% CI 1.2-2.1). There was no previous joint disease or medical illness in 54%. The commonest joints involved were the knee (54%) and hip (13%). Significant age associations were infected hips in those under 15 years and infected knees in those over 45 years. Seventy two percent of infections were haematogenous. Causative organisms included Staphylococcus aureus (37%), Streptococcus pyogenes (16%) and Neisseria gonorrhoeae (12%). Unusual infections included three melioidosis cases. Polyarthritis occurred in 17%, with N. gonorrhoeae (11/23) more likely to present as polyarthritis than other organisms (22/168) (OR 6.0; 95% CI 2.1-16.7). Univariate and multivariate analysis showed the hip to be at greater risk for S. aureus than other joints. Open arthrotomy was a more successful treatment procedure than arthroscopic washout or needle aspiration.
澳大利亚北部热带地区的皇家达尔文医院对191例脓毒性关节炎病例进行了一项回顾性研究。总体发病率为每10万人中9.2例,澳大利亚原住民的发病率为每10万人中29.1例(相对危险度6.6;95%可信区间5.0 - 8.9)。男性受累多于女性(相对危险度1.6;95%可信区间1.2 - 2.1)。54%的患者既往无关节疾病或内科疾病。最常受累的关节是膝关节(54%)和髋关节(13%)。显著的年龄关联是15岁以下人群中髋关节感染,45岁以上人群中膝关节感染。72%的感染为血源性感染。病原体包括金黄色葡萄球菌(37%)、化脓性链球菌(16%)和淋病奈瑟菌(12%)。不常见的感染包括3例类鼻疽病例。17%的患者发生多关节炎,淋病奈瑟菌(11/23)比其他病原体(22/168)更易表现为多关节炎(比值比6.0;95%可信区间2.1 - 16.7)。单因素和多因素分析显示,与其他关节相比,金黄色葡萄球菌感染髋关节的风险更高。切开手术是比关节镜冲洗或穿刺抽吸更成功的治疗方法。