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Interaction with glycosaminoglycans is required for cyclophilin B to trigger integrin-mediated adhesion of peripheral blood T lymphocytes to extracellular matrix.亲环蛋白B触发外周血T淋巴细胞与细胞外基质的整合素介导的黏附需要与糖胺聚糖相互作用。
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Involvement of two classes of binding sites in the interactions of cyclophilin B with peripheral blood T-lymphocytes.亲环蛋白B与外周血T淋巴细胞相互作用中两类结合位点的参与情况。
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肾间质成纤维细胞对白细胞趋化因子的表达：与间质纤维化相关药物的上调作用。

Expression of leucocyte chemoattractants by interstitial renal fibroblasts: up-regulation by drugs associated with interstitial fibrosis.

作者信息

González-Cuadrado S, Bustos C, Ruiz-Ortega M, Ortiz A, Guijarro C, Plaza J J, Egido J

机构信息

Renal Research Laboratory, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Spain.

出版信息

Clin Exp Immunol. 1996 Dec;106(3):518-22. doi: 10.1046/j.1365-2249.1996.d01-864.x.

DOI:10.1046/j.1365-2249.1996.d01-864.x
PMID:8973621
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2200627/
Abstract

Interstitial inflammation is a strong predictor of long-term renal damage. The potential role of renal interstitial fibroblasts in recruitment of inflammatory leucocytes into the interstitium is unclear. We have thus studied the mRNA expression of several leucocyte chemotactic factors by rat renal interstitial fibroblasts and its modulation by cytokines. In addition, the effects of two unrelated drugs associated with the development of interstitial fibrosis, namely puromycin aminonucleoside (PAN) and cyclosporin A (CsA), were also studied. Rat renal interstitial fibroblasts showed constitutive mRNA expression for the chemokines monocyte chemoattractant protein 1 (MCP-1) and interferon-inducible protein 10 (IP-10). In addition, these cells also exhibited constitutive mRNA expression for cyclophilin B, an immunophilin recently found to have leucocyte chemoattractant properties. The inflammatory cytokine tumour necrosis factor-alpha up-regulated IP-10 and MCP-1 mRNA expression (10- and four-fold, respectively), but had no effect on cyclophilin B mRNA levels. IP-10 and MCP-1 produced about a four-fold increase in MCP-1 and cyclophilin B mRNA expression, but did not affect IP-10 mRNA. PAN caused an augmentation in IP-10, MCP-1 and cyclophilin B mRNA levels (12-, 9.5, and two-fold, respectively), while CsA increased only cyclophilin B mRNA in a dose-dependent manner. In conclusion, rat renal interstitial fibroblasts express mRNA for chemotactic factors and this expression is up-regulated by inflammatory cytokines, PAN and CsA. The present findings suggest that renal interstitial fibroblasts may play an active role in the recruitment of inflammatory leucocytes into the interstitium.

摘要

间质炎症是长期肾脏损害的有力预测指标。肾间质成纤维细胞在炎症白细胞募集到间质中的潜在作用尚不清楚。因此，我们研究了大鼠肾间质成纤维细胞中几种白细胞趋化因子的mRNA表达及其受细胞因子的调节。此外，还研究了与间质纤维化发展相关的两种无关药物，即嘌呤霉素氨基核苷（PAN）和环孢素A（CsA）的作用。大鼠肾间质成纤维细胞显示趋化因子单核细胞趋化蛋白1（MCP-1）和干扰素诱导蛋白10（IP-10）的组成型mRNA表达。此外，这些细胞还表现出亲环素B的组成型mRNA表达，亲环素B是一种最近发现具有白细胞趋化特性的亲免素。炎性细胞因子肿瘤坏死因子-α上调了IP-10和MCP-1的mRNA表达（分别上调了10倍和4倍），但对亲环素B的mRNA水平没有影响。IP-10和MCP-1使MCP-1和亲环素B的mRNA表达增加了约4倍，但不影响IP-10的mRNA。PAN导致IP-10、MCP-1和亲环素B的mRNA水平升高（分别升高了12倍、9.5倍和2倍），而CsA仅以剂量依赖的方式增加亲环素B的mRNA。总之，大鼠肾间质成纤维细胞表达趋化因子的mRNA，并且这种表达受炎性细胞因子、PAN和CsA上调。目前的研究结果表明，肾间质成纤维细胞可能在炎症白细胞募集到间质中发挥积极作用。