Luukkainen R, Isomäki H, Kajander A
Scand J Rheumatol. 1977;6(2):123-7. doi: 10.3109/03009747709095434.
The progressive of erosive X-ray changes over a period of 5-6 years was evaluated in RA patients with a low or high dose of gold during the follow-up period. The "low gold" group included 18 patients whose treatment was discontinued because of side effects at a mean dose of 254 mg of Myocrisin. The "high gold" group included 32 patients who received a mean dose of 1858 mg of Myocrisin. Both the number of eroded joints in the hands and feet and the X-ray stage had deteriorated more in the "low gold" group. The inter-group difference was statistically significant. Thus, gold treatment has a retarding effect on the progression of erosions in RA patients.
在随访期间，对接受低剂量或高剂量金制剂治疗的类风湿关节炎（RA）患者，评估其5 - 6年期间侵蚀性X线改变的进展情况。“低剂量金制剂”组包括18例患者，他们因副作用在平均剂量为254毫克米诺春时停止治疗。“高剂量金制剂”组包括32例患者，他们接受的米诺春平均剂量为1858毫克。“低剂量金制剂”组患者的手足侵蚀关节数量和X线分期恶化程度均更大。组间差异具有统计学意义。因此，金制剂治疗对RA患者侵蚀的进展具有延缓作用。
