Luukkainen R, Isomäki H, Kajander A
Rheumatol Rehabil. 1978;Suppl:94-8. doi: 10.1093/rheumatology/xvii.suppl.94.
The progression of erosive X-ray changes over a period of 5--6 years was evaluated in 39 patients exposed to a mean dose of 2030 mg aurothiomalate during the maintenance period. The cause for the low dose was the initial high incidence of side-effects. The progression of erosions was highest in patients with the low dose of gold in the initial stages of the disease. The best result in preventing development of erosions was achieved in patients with the high dose of gold in the early phase of the disease. It appears that gold treatment prevents the progression of the erosoins. The earlier the inception of treatment, the better the result.
对39例在维持期平均接受2030毫克硫代苹果酸金钠剂量的患者，评估其在5至6年期间侵蚀性X线改变的进展情况。低剂量的原因是初始阶段副作用发生率高。在疾病初始阶段接受低剂量金治疗的患者中，侵蚀进展最为明显。在疾病早期接受高剂量金治疗的患者中，预防侵蚀发展的效果最佳。似乎金治疗可阻止侵蚀的进展。治疗开始得越早，效果越好。
